Patients with polycythaemia vera (PV), essential thrombocythemia (ET) or primary myelofibrosis (PMF) are at an increased risk of arterial and venous thrombosis compared with patients with chronic myeloid leukemia (CML).
In patients with ET, a positive correlation was observed between JAK-2 V617F mutation (which facilitates erythropoietin receptor signalling) and

Elderly type 2 diabetic (T2DM) patients have many comorbidities that can affect their overall prognosis. Therefore, the analysis of comorbidities is of major importance.
This study evaluated the management of diabetes in elderly patients with Parkinson's disease and how their prognosis is affected.

Low molecular weight heparins (LMWH) are commonly used in prevention and treatment of thrombosis in cancer patients. An anti-metastatic effect has also been discussed and could increase survival in patients, regardless of antithrombotic effects.
The objective of this study was to understand the potential interactions between LMWH treatment and treatment of ovarian cancer with cisplatin...

Predictive factors for venous thromboembolism (VTE) and their recurrence in patients with cancer are poorly understood. Thus, the research for biomarkers of deep vein thrombosis (DVT) would identify high risk patients and potentially adapt anticoagulant therapy.
Since the early 1990s, the angiogenic switch, i.e. the transition of tumours to the metastatic stage, has been attributed to peritumoral vascular growth and particularly to the main

Tumour vasculature and broadly speaking, actors in angiogenesis are therapeutic targets in cancer. The response to treatment could be assessed by circulating cellular biomarkers, circulating endothelial cells (CEC) or endothelial progenitor cells (EPC).
CECs may reflect the active remodelling...

The differentiation of tumour cells into endothelial cells in situ has been proposed in glioblastoma, but this process is still largely unexplored. The relevance of this transdifferentiation as well as the role of VEGF and its receptors remains to be elucidated. Moreover, this phenomenon has only been reported in glioblastomas.